abstract：:Transient global amnesia (TGA) is a clinical syndrome of unknown etiology characterized by sudden onset anterograde amnesia, which was thought to resolve completely. However, some authors have also suggested permanent memory impairment. It is unclear whether these results reflect a true persistent damage or a simply t...

journal_title：European neurology

authors： Uttner I,Weber S,Freund W,Schmitz B,Ramspott M,Huber R

更新日期：2007-01-01 00:00:00

abstract：:SJL/J mice have been studied as the model animals for autoimmunological diseases. Recently it was clarified that SJL/J mice have a defect of dysferlin. Human limb girdle muscular dystrophy 2B and Miyoshi myopathy also have a defect of dysferlin. In this study we present the histological and immunohistological changes ...

journal_title：European neurology

authors： Nemoto H,Konno S,Nakazora H,Miura H,Kurihara T

更新日期：2007-01-01 00:00:00

abstract：:The cerebral hemispheres show prominent involvement in hypertensive encephalopathy far more frequently than the brainstem. Two patients with severe paroxysmally accelerated hypertension associated with brainstem hyperintensity in T2-weighted magnetic resonance images are presented. Both present hyperintense lesions im...

journal_title：European neurology

authors： Uchino M,Haga D,Nomoto J,Mito T,Kuramitsu T

更新日期：2007-01-01 00:00:00

abstract：:Leonardo da Vinci clearly observed and described capillaries. Using the microscope, Marcello Malpighi examined the brain and major organs to demonstrate their finer anatomical features. This led to his discovery in 1661, of capillaries that proved fundamental to our understanding of the vascular system in the brain an...

journal_title：European neurology

authors： Pearce JM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy. METHODS:We pre...

journal_title：European neurology

authors： Thomas JE,Lee N,Thompson PD

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral infarction (CI) occurring soon after intracerebral hemorrhage (ICH) has been rarely reported. The purpose of the present study was to characterize this condition and discuss the possible pathophysiology. METHOD:We retrospectively studied 6 patients who developed CI within 10 days after ...

journal_title：European neurology

authors： Kim CH,Kim JS

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the diagnostic yield of nerve biopsy in patients with peripheral neuropathy of undetermined cause despite extensive diagnostic workup. METHODS:From November 2001 through January 2004, 38 patients underwent nerve biopsy because of unclassified neuropathy. RESULTS:The etiology of the neuropathies...

journal_title：European neurology

authors： Schweikert K,Fuhr P,Probst A,Tolnay M,Renaud S,Steck AJ

更新日期：2007-01-01 00:00:00

abstract：:Synaesthesia is the intriguing, involuntary experience of feeling one sensation in response to a different sensory stimulus. Recognised since described in 1890 by John Locke and clarified by Galton in the 1880s, it has been analysed in the last 50 years. Grapheme-colour synaesthesia is the commonest form, but many oth...

journal_title：European neurology

authors： Pearce JM

更新日期：2007-01-01 00:00:00

abstract：:This study investigated the maximum number of collaterals that can be maintained by 1 axon during regeneration of rat peripheral nerve. The tibial nerve was transected, the proximal residual, with its variable number of axons, was fixed to the distal stump and served as the donor nerve. The number of myelinated axons ...

journal_title：European neurology

authors： Jiang BG,Yin XF,Zhang DY,Fu ZG,Zhang HB

更新日期：2007-01-01 00:00:00

abstract：:Previous findings regarding the role of TNF-alpha-308 gene polymorphism in multiple sclerosis (MS) are contradictory. The aim of this study was to investigate the possible influence of TNF-alpha-308 polymorphism on MS susceptibility and the MS disease process in a Croatian and Slovenian population. Genotyping was perf...

journal_title：European neurology

authors： Ristić S,Lovrecić L,Starcević-Cizmarević N,Brajenović-Milić B,Sega Jazbec S,Sepcić J,Kapović M,Peterlin B

更新日期：2007-01-01 00:00:00

abstract：:Oxidative stress and generation of reactive oxygen species are believed to be implicated in Parkinson's disease (PD). Erythrocyte activity of superoxide dismutase (SOD) and catalase, the blood glutathione system, and plasma levels of thiobarbituric-acid-reactive substances (TBARS) were measured in 80 PD patients. Thes...

journal_title：European neurology

authors： Younes-Mhenni S,Frih-Ayed M,Kerkeni A,Bost M,Chazot G

更新日期：2007-01-01 00:00:00

abstract：:This paper records a patient of Osler's, who showed many features compatible with the Churg-Strauss syndrome of allergic granulomatous angiitis to be described 50 years later. ...

journal_title：European neurology

authors： Pearce JM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Several testing options are available to detect asymptomatic coronary artery disease (CAD). Dobutamine stress echocardiography (DSE) has been reported to increase the sensitivity and specificity of stress testing to detect CAD. Most studies concerned patients with known or suspected CAD who have a high prete...

journal_title：European neurology

authors： Nighoghossian N,Cakmak S,Derex L,Barthelet M,Thibault H,Finet G,Ovize M,Derumeaux G,Nemoz C,Chapuis F,Rioufol G

更新日期：2006-01-01 00:00:00

abstract：:This study assessed gender differences in diabetic patients with ischemic stroke with respect to vascular risk factors, clinical features and early outcome. Ischemic stroke was diagnosed in 261 diabetic women and 300 diabetic men of 2,446 ischemic stroke patients included in a prospective stroke registry over 17 years...

journal_title：European neurology

authors： Arboix A,Milian M,Oliveres M,García-Eroles L,Massons J

更新日期：2006-01-01 00:00:00

abstract：PRIMARY OBJECTIVE:To determine whether the ipsilateral cortex surrounding the lesion or the non-injured contralateral cortex is important for motor recovery after brain damage in the photochemically initiated thrombosis (PIT) model. RESEARCH DESIGN:We induced PIT in the sensorimotor cortex in rats and examined the rec...

journal_title：European neurology

authors： Takata K,Yamauchi H,Tatsuno H,Hashimoto K,Abo M

更新日期：2006-01-01 00:00:00

abstract：:The production of novel, motivated or useful material defines creativity, which appears to be one of the higher, specific, human brain functions. While creativity can express itself in virtually any domain, art might particularly well illustrate how creativity may be modulated by the normal or pathological brain. Evid...

journal_title：European neurology

authors： Bogousslavsky J

更新日期：2005-01-01 00:00:00

abstract：:The serum concentration of S-100B is reported to reflect the severity of brain damage. The purpose of this study was to determine whether elevated serum S-100B concentrations were related to neuropsychological test performance of patients in the subacute phase of recovery from mild traumatic brain injury (TBI). S-100B...

journal_title：European neurology

authors： Stapert S,de Kruijk J,Houx P,Menheere P,Twijnstra A,Jolles J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Seizures and epilepsy are harmful and worsen the disability of stroke patients. There are currently no good clinical predictors of late-onset seizures and epilepsy in patients with cerebrovascular disease (CVD). PATIENTS AND METHODS:110 patients with delayed seizures after an ischaemic or a haemorrhagic str...

journal_title：European neurology

authors： De Reuck J,Goethals M,Vonck K,Van Maele G

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Previous studies showed that late-life depression with subjective memory complaints (SMC) may be associated with an increased risk of developing dementia. However, not all such patients have cognitive decline. The aim of this longitudinal study was to identify possible clinical determinants of progressive de...

journal_title：European neurology

authors： von Gunten A,Giannakopoulos P,Duc R

更新日期：2005-01-01 00:00:00

abstract：:Missed cerebral aneurysms in CT-negative patients can have serious implications. We set out to determine the usefulness of cerebrospinal fluid (CSF) spectrophotometry and the individual significance of CSF oxyhaemoglobin, bilirubin and methaemoglobin in 463 CT scan-negative patients with suspected subarachnoid haemorr...

journal_title：European neurology

authors： Gunawardena H,Beetham R,Scolding N,Lhatoo SD

更新日期：2004-01-01 00:00:00

abstract：:To investigate the association between APOE-epsilon4 allele and memory phenotype in the preclinical stage of Alzheimer's disease (AD). We compared an extensive preclinical memory profile at the baseline evaluation of 2 AD genotype groups: APOE-epsilon4 allele carriers and patients with APOE-epsilon3 homozygosity. Base...

journal_title：European neurology

authors： Estévez-González A,García-Sánchez C,Boltes A,Otermín P,Baiget M,Escartín A,del Rio E,Gironell A,Kulisevsky J

更新日期：2004-01-01 00:00:00

abstract：:Sir William Gull coined the name 'anorexia nervosa'. Examples of self-starvation appeared in the Hellenistic era. Holy anorexics abused their bodies, rejected marriage and sought religious asylum where many perished and became saints. The condition then paled into obscurity until the 19th century. Louis-Victor Marce (...

journal_title：European neurology

authors： Pearce JM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Antioxidant enzymes like copper/zinc superoxide dismutase (SOD), catalase and gluthatione peroxidase (GSHPx) are part of intracellular protection mechanisms to overcome oxidative stress and are known to be activated in vascular diseases and acute stroke. We investigated the differences of antioxi...

journal_title：European neurology

authors： Zimmermann C,Winnefeld K,Streck S,Roskos M,Haberl RL

更新日期：2004-01-01 00:00:00

abstract：:Divers may be at risk of long-term CNS damage from non-symptomatic hyperbaric exposure. We investigated the effect of severe, controlled hyperbaric exposure on a group of healthy goats with similar histories. Thirty goats were exposed to various dive profiles over a period of 5 years, with 17 experiencing decompressio...

journal_title：European neurology

authors： Blogg SL,Loveman GA,Seddon FM,Woodger N,Koch A,Reuter M,Gennser M,White MG

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Neurosyphilis (NS) is nowadays a less frequent disease. Its incidence and clinical spectrum have changed over time. OBJECTIVE:To estimate the incidence of NS and describe the clinical spectrum of NS in immunocompetent patients in the last decade. METHODS:Demographic and clinical features, cerebrospinal flu...

journal_title：European neurology

authors： Conde-Sendín MA,Amela-Peris R,Aladro-Benito Y,Maroto AA

更新日期：2004-01-01 00:00:00

abstract：:Long-term development of psychological deficits in disability-free early multiple sclerosis (MS) was evaluated in 27 female patients over a period of 7 years and compared with healthy controls. Physical and cognitive parameters deteriorated significantly but not depression scores. In particular, the self-assessed soma...

journal_title：European neurology

authors： Haase CG,Tinnefeld M,Daum I,Ganz RE,Haupts M,Faustmann PM

更新日期：2004-01-01 00:00:00

abstract：:The hypothesis that mitochondrial genes may implicate susceptibility to multiple sclerosis (MS) is supported by an increasing number of case reports on Leber's hereditary optic neuropathy (LHON)-associated mitochondrial DNA (mtDNA) point mutations in patients with MS. A number of mtDNA mutations with primary pathogeni...

journal_title：European neurology

authors： Houshmand M,Sanati MH,Rashedi I,Sharifpanah F,Asghari E,Lotfi J

更新日期：2004-01-01 00:00:00

abstract：:Botulinum toxin type B (BT-B) therapy failure due to formation of botulinum toxin type B antibodies (BT-B-AB) has only been reported in patients with botulinum toxin type A antibodies (BT-A-AB). We are reporting BT-B-AB-induced therapy failure in 2 patients with no previous exposure to botulinum toxin. In patient 1 co...

journal_title：European neurology

authors： Dressler D,Bigalke H

更新日期：2004-01-01 00:00:00

abstract：:Trials of pharmacological intervention for acute stroke show several points of similarity with legal trials by jury. The relationships between sponsoring organisation and regulatory authorities and the roles of the many other participants are described. Only through a partnership can the common aim of developing impro...

journal_title：European neurology

authors： Lees KR

更新日期：2003-01-01 00:00:00

abstract：:We examined interleukin-2 (IL-2) production by phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMs) from 75 untreated myasthenia gravis (MG) patients and 48 control patients. Patients with MG consisted of those with elevated PBM IL-2 production (>1,250 pg/ml; mean + 2SD of the controls) (n = 2...

journal_title：European neurology

authors： Utsugisawa K,Nagane Y,Obara D,Kondoh R,Yonezawa H,Tohgi H

更新日期：2003-01-01 00:00:00

abstract：:The objective of this work was to precisely analyse the reduction of the antiparkinsonian treatment in 18 consecutive patients with Parkinson's disease (PD) operated on for bilateral subthalamic nucleus (STN) stimulation, first after 1 month of follow-up, then at 1 year postoperatively. Trihexyphenidyle, selegiline, e...

journal_title：European neurology

authors： Thobois S,Corvaisier S,Mertens P,Di Guardo C,Mollion H,Guenot M,Rochefort F,Chazot G,Sindou M,Broussolle E

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To study gender differences of coping with illness strategies in tension-type headaches. METHOD:We enrolled 89 subjects (50 women, 39 men) suffering from episodic (n = 37) and chronic (n = 52) tension-type headaches (TTH). Patients were required to answer a Freiburg Questionnaire of Coping with Illness (FQCI...

journal_title：European neurology

authors： Rollnik JD,Karst M,Piepenbrock S,Gehrke A,Dengler R,Fink M

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND STUDY PURPOSE:Autonomic nervous system dysfunction is a common complication of acute cerebrovascular disorders. The aim of this study was to investigate a possible location-dependent difference in cardio-autonomic function in patients with ischaemic stroke. PATIENTS AND METHODS:Sympathetic function was ...

journal_title：European neurology

authors： Strittmatter M,Meyer S,Fischer C,Georg T,Schmitz B

更新日期：2003-01-01 00:00:00

abstract：:We examined 29 patients with chronic progressive ganglionopathy of different etiology. Neurophysiological abnormalities were dominated by a widespread decrease in sensory nerve action potential amplitudes, which involved both upper and lower limb nerves, even in patients with asymmetrical or patchy clinical presentati...

journal_title：European neurology

authors： Lauria G,Pareyson D,Sghirlanzoni A

更新日期：2003-01-01 00:00:00

abstract：:Increased levels of lactic dehydrogenase (LDH) in cerebrospinal fluid (CSF) have been reported in association with several intracranial pathologies. We studied LDH isoenzymes in the CSF of children with infantile spasms. CSF samples collected from 12 patients (aged 4-9 months) with infantile spasms were analyzed for t...

journal_title：European neurology

authors： Nussinovitch M,Harel D,Eidlitz-Markus T,Amir J,Volovitz B

更新日期：2003-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the contribution of the postsynaptic mechanism to the development of motor fluctuation in advanced Parkinson's disease (PD). We used 123I-iodobenzamide single-photon emission computed tomography to measure the striatal dopamine D2 receptor densities in early levodopa-naïve PD,...

journal_title：European neurology

authors： Hwang WJ,Yao WJ,Wey SP,Shen LH,Ting G

更新日期：2002-01-01 00:00:00

abstract：:Machado-Joseph disease (MJD) is a dominantly inherited cerebellar ataxia associated with spasticity, ophthalmoplegia, dystonia and peripheral neuropathy. Presented here are 5 MJD cases. A morphometric analysis of the histopathology of their sural nerves was carried out to know the relationship between axon size and my...

journal_title：European neurology

authors： Lin KP,Soong BW

更新日期：2002-01-01 00:00:00

abstract：:We have recently observed a diffuse slowing of brain waves using serial quantitative electroencephalographic (qEEG) examinations in interferon (IFN)-alpha-treated chronic hepatitis C patients. However, it remains unclear how this alteration could be assessed. We evaluated the correlation between the qEEG changes and t...

journal_title：European neurology

authors： Kamei S,Sakai T,Matsuura M,Tanaka N,Kojima T,Arakawa Y,Matsukawa Y,Mizutani T,Oga K,Ohkubo H,Matsumura H,Hirayanagi K

更新日期：2002-01-01 00:00:00

abstract：:We report a 60-year-old right-handed Japanese man who showed an isolated persistent typing impairment without aphasia, agraphia, apraxia or any other neuropsychological deficit. We coined the term 'dystypia' for this peculiar neuropsychological manifestation. The symptom was caused by an infarction in the left frontal...

journal_title：European neurology

authors： Otsuki M,Soma Y,Arihiro S,Watanabe Y,Moriwaki H,Naritomi H

更新日期：2002-01-01 00:00:00

abstract：:The consequences of cerebral infarcts involving the left hemisphere differ from those of the right homologue areas. Data of 337 consecutive, unselected patients with acute ischaemic stroke in the territory of the right or left middle cerebral artery were analysed. Furthermore, lesion locations of 77 stroke patients wi...

journal_title：European neurology

authors： Aszalós Z,Barsi P,Vitrai J,Nagy Z

更新日期：2002-01-01 00:00:00